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Given that, most of the evidence derives from studies utilizing a cross-sectional design, the association of tramadol with seizures should not be considered to be definitively established. Conclusions: Our results demonstrate that the occurrence of seizures in patients exposed to tramadol are dose-dependent and related to male gender, but not related to naloxone administration. Naloxone administration was not associated to the occurrence of seizures (pooled OR: 0.47, 95% CI: 0.15-1.49). Hydrocodone and ibuprofen may also be used for purposes not listed in this medication guide. Hydrocodone and ibuprofen is a combination medicine that is used short-term to relieve severe pain. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). Severe Pain Steroidal injection Opioid analgesics Morphine, Fentanyl, Percocet, Codeine, Vicodin. the counter Acetaminophen, Non-steroidal anti-inflammatory drugs (NSAIDs), Topical Prescription Muscle relaxants, Anti-anxiety, Antidepressants, NSAIDs. An opioid is occasionally called a narcotic. Acetaminophen is a less potent pain reliever that increases the effects of hydrocodone.
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The odds for occurrence of seizures were significantly associated with male gender (pooled OR: 2.24, CI 95%: 1.80-2.77). Hydrocodone is an opioid pain medication, sometimes called a narcotic. stroke and cancer combined Costs our society 635 billion annually. Vicodin contains a mixture of hydrocodone and acetaminophen. 20mg OLM under the tongue is quicker where pain is extreme. (MP) patients should always use 40mg of every four hours, or more often, before resorting to. Tramadol dose was significantly higher in the patients with seizures than those without (mean differences: 0.82, CI 95%: 0.17-1.46). Pain is a symptom of and can be exacerbated by. The results showed that seizure event rate in the subgroups of tramadol poisoning, therapeutic dosage of tramadol, and tramadol abusers was 38% (95% CI: 27-49%), 3% (95% CI: 2-3%), 37% (95% CI: 12-62%), respectively. Results: A total of 51 articles with total sample size of 101 770 patients were included. Forest plots demonstrating the point and pooled estimates were drawn. Heterogeneity between the studies was assessed with using I-square and Q-test. The risk of bias was assessed using the Newcastle-Ottawa Scale After article quality assessment, a fixed or random model, as appropriate, was used to pool the results in a meta-analysis. Cohort, case-control, cross-sectional studies, and clinical trials. Two researchers systematically searched PubMed/Medline, Web of Sciences, and Scopus. Methodology: Our systematic review is compliant with PRISMA guidelines. The present study aims to investigate and summarize the studies related to tramadol and occurrences of seizures after tramadol use and factors influencing these seizures. One of the serious possible complications of its use is seizures. Introduction: Tramadol is a synthetic opioid which is commonly used around the world to relieve moderate to severe pain.